We are a lab of undergraduate and masters students, committed to furthering understanding of the effects of small molecules on the Nrf2/ARE pathway and on cytoprotection of cellular integrity. Our research interests include the effects of electrophiles and redox-active small molecules, in particular quinones and hydroquinones, better understanding of effects which widen or narrow the therapeutic window of Nrf2 activators, and how combinations of small molecules can act synergistically or antagonistically on the pathway. Our most recent work uncovered opposing effects of reactive oxygen species (ROS) on activation of the Nrf2 pathway by the clinically-investigated molecule sulforaphane. The ROS-generating molecule di-tert-butylhydroquinone (dtBHQ) widens the therapeutic window of sulforaphane, increasing its potency while having no effect on its toxicity at high concentrations. However, dtBHQ paradoxically also suppresses the levels of Nrf2, the transcription factor required for this activation. This work provides a model system for understanding the effects of small molecule co-treatment on this pathway, which ultimately could lead to better prevention of chronic diseases.  

Dr. Aimee Eggler
Profile and contact information
CV
Classes taught:
CHM 4622 Biochemistry II: Metabolism
CHM 4601 Survey of Biochemistry
CHM 4603 Biochemistry Techniques & Practice
CHM 4664/9664 Signal Transduction
CHM 1103 General Chemistry Laboratory I

Masters students (italics indicates graduation)

Elizabeth Repash (September 2017 – May 2018)

Matthew Savage (June 2016 – May 2018) Scientist with Pharmaceutical Product Development (PPD) at Vertex Pharmaceuticals, Boston, MA

Gwenny Go (September 2016 – May 2018) Manufacturing Associate with WuXi AppTec, Philadelphia, PA

Bradly Bauman (January 2014 – August 2015) Research Assistant for the Henry M. Jackson Foundation for the Advancement of Military Medicine

Zachary Kemmerer (August 2012 – July 2014) Ph.D. program, University of Wisconsin-Madison

Undergraduates (italics indicates graduation)

Kaitlin Pensabene (September 2018 – Present), Sophomore

Maria Delgado (June 2018 – Present), Senior

Kayla Byrnes (September 2017 – Present), Junior

Claudia Macpherson (September 2017 – Present), Senior

Chang Jeong (June 2016 – May 2018)                       

Anish Vora(Summer of 2016), M.D. program, Lewis Katz School of Medicine at Temple University

Mykal Gerald (December 2015 – May 2018), M.D. program, Lewis Katz School of Medicine at Temple University        

Alexandra Elder(May 2015 – May 2017), M.D. program, Sidney Kimmel Medical College at Thomas Jefferson University        

Anna Briker(January 2014 – May 2017), M.D. program, Northwestern Feinberg School of Medicine               

Linda Nguyen(January 2014 – Present), Masters of Public Health program, Columbia University Mailman School of Public Health     

Nicholas Janigian(January 2015– May 2016), AmeriCorps Notre Dame Education Center in Boston, 1 year; M.D. program, Lewis Katz School of Medicine at Temple University    

Prabhjot Kaur(September 2014 – May 2016) 

Rebecca Lin(May 2013 – May 2016), M.D. program, Lewis Katz School of Medicine at Temple University

Nicholas Ader(September 2014 – May 2015) Ph.D. program, Cambridge/National Institutes of Health

Sarah Mulroy(August 2012 – May 2014) Employed at Epic Systems, Verona WI

Rachel Young(May 2012 – May 2014) Jesuit Volunteer Corps

Yannis Koukounas(February 2013 – May 2014) Pharm. D. program, University of Wisconsin-Madison

Other Trainees
Lingdian Kong (September 2017– Present), High school student at the Agnes Irwin school
Madhuparna Chakraborty (May 2017 – July 2017) MS in Biology, summer internship in our lab

Bridget Murray (May 2017-August 2017) Senior at University of Pittsburgh, summer internship in our lab