The Eggler Research Group
A lab of undergraduate and masters students, our research centers on the NRF2 transcription factor, a primary way in which our bodies sense and recover from environmental and internal stressors. Activation of NRF2 through diet, exercise, supplementation, and pharmacological intervention is a promising means of combating a wide range of chronic diseases, including asthma, cancer, arthritis, multiple sclerosis, and many more. For example, there are over 90 clinical trials on the use of a potent NRF2 activator found in high concentrations in broccoli sprouts, sulforaphane, to treat these conditions and others.
(Undergraduate authors underlined, Masters authors in italics)
Pensabene, K. M., LaMorte J., Allender, A.E., Wehr, J., Kaur P., Savage, M., Eggler, A.L., (2023). Acute oxidative stress suppresses Nrf2 protein synthesis by inhibiting global protein translation. Antioxidants 12, 1735. DOI: 10.3390/antiox12091735
Grady, R. S., Traustadottir, T., Lagalante, A.F., Eggler, A.L., (2023). Bioavailable sulforaphane quantitation in plasma by LC-MS/MS is enhanced by blocking thiols. Journal of Agricultural and Food Chemistry, 71, 12875–12882. DOI: 10.1021/acs.jafc.3c01367