The Eggler Research Group

Department of Chemistry
Villanova University

Our lab

A lab of undergraduate and masters students, our research centers on the NRF2 transcription factor, a primary way in which our bodies sense and recover from environmental and internal stressors. Activation of NRF2 through diet, exercise, supplementation, and pharmacological intervention is a promising means of combating a wide range of chronic diseases, including asthma, cancer, arthritis, multiple sclerosis, and many more. For example, there are over 90 clinical trials on the use of a potent NRF2 activator found in high concentrations in broccoli sprouts, sulforaphane, to treat these conditions and others.

Recent Publications

(Undergraduate authors underlined, Masters authors in italics)

Pensabene, K. M., LaMorte J., Allender, A.E., Wehr, J., Kaur P., Savage, M., Eggler, A.L., (2023). Acute oxidative stress suppresses Nrf2 protein synthesis by inhibiting global protein translation. Antioxidants 12, 1735. DOI: 10.3390/antiox12091735

Grady, R. S., Traustadottir, T., Lagalante, A.F., Eggler, A.L., (2023). Bioavailable sulforaphane quantitation in plasma by LC-MS/MS is enhanced by blocking thiols. Journal of Agricultural and Food Chemistry, 71, 12875–12882. DOI: 10.1021/acs.jafc.3c01367

Current Grants

Aimee Eggler, PhD

(610) 519-4878

Faculty Profile